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Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.
Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF. Um K, et al. Dev Cell. 2014 Jun 23;29(6):701-15. doi: 10.1016/j.devcel.2014.05.011. Dev Cell. 2014. PMID: 24960694 Free PMC article.
Here, we identify a regulatory complex composed of a Rac-GEF (Tiam1) and a Rac-GAP (Bcr) that cooperate to control excitatory synapse development. Disruption of Bcr function within this complex increases Rac1 activity and dendritic spine remodeling, resulting in excessive …
Here, we identify a regulatory complex composed of a Rac-GEF (Tiam1) and a Rac-GAP (Bcr) that cooperate to control excitatory synapse …
The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity.
Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF. Narayanan AS, et al. Mol Biol Cell. 2013 Dec;24(24):3857-68. doi: 10.1091/mbc.E13-06-0333. Epub 2013 Oct 23. Mol Biol Cell. 2013. PMID: 24152735 Free PMC article.
The Par complex (Par3, Par6, and PKCzeta) controls cell polarity in part by recruiting the Rac-specific guanine nucleotide exchange factor T-lymphoma invasion and metastasis 1 (Tiam1) to specialized cellular sites, where Tiam1 promotes local Rac1 activation and cyto …
The Par complex (Par3, Par6, and PKCzeta) controls cell polarity in part by recruiting the Rac-specific guanine nucleotide exchange factor T …