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2013 | 1 |
2014 | 1 |
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Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.
Dev Cell. 2014 Jun 23;29(6):701-15. doi: 10.1016/j.devcel.2014.05.011.
Dev Cell. 2014.
PMID: 24960694
Free PMC article.
Here, we identify a regulatory complex composed of a Rac-GEF (Tiam1) and a Rac-GAP (Bcr) that cooperate to control excitatory synapse development. Disruption of Bcr function within this complex increases Rac1 activity and dendritic spine remodeling, resulting in excessive …
Here, we identify a regulatory complex composed of a Rac-GEF (Tiam1) and a Rac-GAP (Bcr) that cooperate to control excitatory synapse …
The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity.
Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF.
Narayanan AS, et al.
Mol Biol Cell. 2013 Dec;24(24):3857-68. doi: 10.1091/mbc.E13-06-0333. Epub 2013 Oct 23.
Mol Biol Cell. 2013.
PMID: 24152735
Free PMC article.
The Par complex (Par3, Par6, and PKCzeta) controls cell polarity in part by recruiting the Rac-specific guanine nucleotide exchange factor T-lymphoma invasion and metastasis 1 (Tiam1) to specialized cellular sites, where Tiam1 promotes local Rac1 activation and cyto …
The Par complex (Par3, Par6, and PKCzeta) controls cell polarity in part by recruiting the Rac-specific guanine nucleotide exchange factor T …
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